ORGN 414 |
| Galactosylated cationic compounds (I-IV) for targeted gene delivery were synthesized. These compounds contain three segments, polyamine segment for DNA binding, trigalactose segments for target binding, and an aliphatic chain for connecting the two functional segments. DAB dendr-(Am)4 (generation 1) with hydrocarbon chain was used as a scaffold for attachment of three galactosides, while the end of hydrocarbon chain was linked to DAB-dendr-(Am)n (I, III, n=16, generation 3, II, IV, n=32, generation 4) through carbomate bond. Galactose moieties were introduced to the compounds by either an ether bond (I, II) or a thiourea bond (III, IV).
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |
