ORGN 604 |
| Our research goal is to generate a dynamic combinatorial library of novel cyclic peptidomimetics using reversible cross-metathesis. The constituents of our library are made by cross-metathesis of amino acid precursors with a cyclic scaffold. A model study has already demonstrated the reactivity and reversibility of the cross-metathesis reaction in our system. We are currently synthesizing various cyclic scaffolds and amino acid derivatives possessing terminal olefin moiety. A small library of cyclic peptidomimetics has been generated, and different templates are now being examined to determine the effects on the dynamic equilibrium.
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Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |
