Total synthesis of (+)-yohimbine

ORGN 35

Dustin J. Mergott, dmergott@fas.harvard.edu and Eric N. Jacobsen, jacobsen@chemistry.harvard.edu. Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA 02138
A total synthesis of yohimbine will be described. The synthetic strategy includes a catalytic asymmetric acyl-Pictet–Spengler reaction and a highly selective intramolecular Diels–Alder reaction.

 

Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 202B, Oral

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005