Syntheses, characterization, and biological properties of two-tail, tri-headed anionic surfactants

ORGN 743

Eko W. Sugandhi, esugandh@vt.edu, Department of Chemistry, Virginia Tech, Davidson Hall, Blacksburg, VA 24061 and Richard D. Gandour, gandour@vt.edu, Department of Chemistry, Virginia Polytechic Institute and State University, Davidson Hall, Blacksburg, VA 24060.
Previous studies show that one of the characteristics of multi-headed surfactants is to increase the solubility of ultra-long chains. Because of this increased solubility, multi-headed surfactants are one of many interesting targets in bioorganic chemistry. We report the syntheses of series of two-tail, tri-headed anionic surfactants based on Newkome type dendrons. These series can be obtained via linear organic syntheses in relatively good yields. Furthermore, we have investigated antimicrobial activities of these surfactants. Similarities and differences on antimicrobial properties of the two different surfactant series will be presented.
 

Lipids, Nucleotides, Biosynthesis, and Mimetics
8:00 AM-12:00 PM, Thursday, 1 September 2005 Washington DC Convention Center -- 202B, Oral

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005