ORGN 413 |
| A simple and efficient method was developed for synthesis of a series of tetraethylenepentamine-based amphiphiles (1-5) that are effective in gene delivery. It involves selective protection of tetraethylenepentamine and the reaction of the protected tetraethylenepentamine with electrophilic reagents, alkylbromide, glycidyl ether and cholesteryl chloroformate, under basic conditions. The yield of the synthesis is above 80%. The detailed synthesis and structure-activity relationship of these new compounds in gene delivery will be presented. This work was supported by a grant from NIH (R01-HL075542).
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |
