ORGN 409 |
| Palladium-phosphinous acids have been reported to be efficient catalysts in various cross-coupling reactions of aryl halides and tosylates. Screening of ten palladium-phosphinous acid catalysts and optimization of reaction conditions revealed that POPd catalyzes Suzuki reaction of a wide range of aryl halides and arylboronic acids to afford the corresponding coupling products in excellent yields under mild reaction conditions. Details of the coupling procedure which affords biaryls from aryl chlorides, bromides and iodides and tolerance of functional groups by this method will be discussed.
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |
