ORGN 602 |
| The employment of tandem reactions in combinatorial chemistry is an expedient way to produce diverse arrays of compounds. We are utilizing the Cobalt mediated Nicholas reaction coupled with subsequent Pauson-Khand reactions or [2+2+2] cyclotrimerizations to access mono- and bi-cyclic frameworks. The obtained cyclopentenone derivatives and aromatic compounds possess core structures found in a variety of natural products and biologically active compounds. Conducting these tandem reactions on a solid-support will greatly facilitate their application in combinatorial and medicinal chemistry. Here, we report initial developments towards this goal. |
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Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |