ORGN 27 |
| The bromotyrosine-derived spiroisoxazolines represent a structurally diverse class of physiologically active natural products. The family contains a number of structural types, including monomeric and dimeric compounds (Figure). Diversity in this natural product class also arises from the spacer diamine element between the two dibromo-spiroisoxazoline moiety. Calafianin (1) is the only member in this group of natural products containing an epoxy ketone moiety. In this presentation, we will review our recent progress towards the synthesis of 1 and dimeric molecules including 2.
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Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 202B, Oral
Division of Organic Chemistry |
