ORGN 586 |
| Prenylated tryptophan-alkaloids, isolated from fungi, are a good example of nature's impressive ability to construct structurally diverse compound libraries from a limited panel of simple starting materials that are structurally not diverse at all. Within this series many bioactive secondary metabolites like the spirotrypostatins with anti-tumor activity have been described and synthesized. We herein report the solid phase synthesis of 6-demethoxy-spirotryprostatin A as well as a library of spiro-pyrrolidine-oxindols, congeners of natural spirotryprostatins on solid phase. |
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Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |