(NHC)Au(I)-Catalyzed (NHC = N-heterocyclic carbene) enyne cycloisomerization

ORGN 370

Nicolas Marion, nmarion@uno.edu1, Pierre de Frémont, megapape@yahoo.fr1, Natalie M Scott1, Louis Fensterbank2, Max Malacria, malacria@ccr.jussieu.fr2, and Steven P. Nolan, snolan@iciq.es3. (1) Chemistry Department, University of New Orleans, 2000 Lakeshore Dr, New Orleans, LA 70148, (2) Laboratoire de chimie organique,UMR 7611, Université Pierre et Marie Curie, 4, Place Jussieu / B. 229, 75005 Paris, France, (3) Nolan group, Institut of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona, Spain
A variety of (NHC)-AuCl (NHC = N-Heterocyclic Carbene) has been synthesized and fully characterized. These complexes, in association with silver salt, have been found to be efficient catalysts in enyne cycloisomerization. Several 1,n-enynes (n = 5, 6, 7) bearing a protected hydroxy group at the propargylic position have been examined leading to different type of cycloisomerized product.

 

Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005