ORGN 425 |
| Sansalvamide is a depsipeptide that belongs to a class of biologically active molecules exhibiting anticancer activity. Because little is known about the mechanism of action of Sansalvamide A, the structure-activity relationship between the active compounds and its biological target may provide information for the development of a new class of anticancer agents. We are synthesizing derivatives of Sansalvamide A using both L and D amino acids. Coupling a tripeptide and a dipeptide forms linear pentapeptides, which are then cyclized to form Sansalvamide derivates. All compounds are confirmed via LCMS and NMR. These compounds are submitted for biological assays with a collaborator who discovered the initial natural product, thus allowing us to compare the structure activity relationship of these derivatives to those of the natural product. |
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |