ORGN 739 |
| DNA has become an attractive material for functional molecules due to its chemical stability and its ability to be directly amplified using the polymerase chain reaction (PCR). A limitation to the use of DNA as a functional molecule is its lowered activity as compared with protein enzymes or antibodies. In an effort to overcome this limitation, the research to be discussed focuses on enhancing the chemical diversity of DNA via the synthesis of modified deoxyuridines (dUTPs) and deoxycytidines (dCTPs). The functionality is introduced at the 5 – position through a carboxyamidation reaction. Because any primary amine can be used for this transformation, it is possible to examine a wide range of structural motifs. The aforementioned modified deoxynucleotides will be incorporated into in vitro selection to aid in the isolation of novel protein aptamers. |
|
Lipids, Nucleotides, Biosynthesis, and Mimetics
8:00 AM-12:00 PM, Thursday, 1 September 2005 Washington DC Convention Center -- 202B, Oral
Division of Organic Chemistry |