ORGN 439 |
| A set of N-terminal protected dipeptides were coupled with a C-terminal methyl ester of either alanine or isoleucine, using various common in situ coupling reagents. These included DCC, EDC, HBTU, TBTU, BOP, PyBrOP or TSTU. Standard coupling protocols for each coupling reagent were followed. After the usual work up, the crude tripeptides were analyzed by reverse phase HPLC. The relative ratios of diasteromers, if any, were compared to see if there is any general trend of racemization, depending on the amino acid(s) and/ or coupling reagents employed. |
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |