Versatile solid-supported active esters: New vistas in acylation and amidation chemistry

ORGN 590

Aubrey J Mendonca, SPE@polymerlabs.com1, Paul A Boguszewski, SPS@polymerlabs.com1, Andrew F Coffey, SPS@polymerlabs.com1, John W Davies, SPS@polymerlabs.com1, Robert A Anderson, SPS@polymerlabs.com2, Alasdair A MacDonald, SPS@polymerlabs.com1, and Frank P Warner, SPS@polymerlabs.com1. (1) Polymer Laboratories Ltd, Now a part of Varian, Inc, Amherst Fields Research Park, 160 Old Farm Road, Amherst, MA 01002, (2) Polymer Laboratories Ltd, Essex Road, Church Stretton, Shropshire, SY6 6AX, United Kingdom
Acylation and amidation are among the most common reactions in modern chemical synthesis. Herein, Polymer Laboratories will report a range of very useful solid supported active ester reagents, which can be used for a range of synthetic transformations. Polymer Laboratories has developed a solid supported reagent, which is highly effective in the conversion of amines to methacrylate or acrylate monomer species. These allow for facile access to a range of functional monomers for high throughput polymer research and polymer therapeutics. The synthesis of diversely functionalized sulfonamides and amines can be achieved in a one pot chemical process, and this will also be described.
 

Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005