ORGN 411 |
| Palladium catalyzed Suzuki cross coupling of aryl halides and triflates with arylboronic acids to form biaryls has emerged as an extremely powerful tool in organic synthesis. Use of arylsulfonate derivatives for these reactions has begun to receive attention due to their ease of preparation and economic considerations. The O6-arylsulfonates of 2'-deoxyguanosine represent conveniently prepared precursors compared to the halo nucleosides. These nucleoside arylsulfonate substrates have therefore been investigated for C-C cross coupling reactions. Results show that there is interplay between several parameters for successful reaction. These include the palladium source, ligand, solvent and base employed, the details of which will be described in greater detail.
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |
