ORGN 412 |
| The Suzuki-Miyaura coupling of arylboronic acids and halo aromatics is a powerful method for the synthesis of biaryl systems. We have previously shown that both 6-chloro- and 6-bromopurine 2'-deoxynucleosides can serve as substrates for C-C cross coupling reactions and that the chloro derivatives exhibit superior properties. These reactions had been performed at elevated temperatures, and the ability to conduct them at room temperature would represent a significant advance. Our results from C-C cross coupling reactions of the chloro nucleosides at room temperature will be presented.
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |
