Knoevenagel reaction revisited: Energy aspects

ORGN 709

Ajay K. Bose, abose@stevens.edu, Subhendu N Ganguly, gangulysn@yahoo.com, Deepu J. Varughese, dvarughe@stevens.edu, and Maghar S. Manhas, mmanhas@stevens.edu. George Barasch Bioorganic Research Laboratory, Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, NJ 07030
The Knoevenagel reaction has long been studied using various solvents along with heating under reflux. We have now investigated a variety of solvent-free reactions of this type with or without microwave irradiation. Observations have been made that reveal the information leading to energy-efficient synthetic procedures especially for larger scale (multimolar) operation and process development. Solvent-free condensation on a molar scale requires less than 30 min for completion. We have studied solvent free reactions because the presence of solvents masks the true energy aspects of these reactions. Microwave irradiation has been used to obtain additional information about the energy picture of endothermic, exothermic and spontaneous reactions types.
 

Heterocycles and Aromatics
8:00 AM-12:00 PM, Thursday, 1 September 2005 Washington DC Convention Center -- Ballroom B, Oral

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005