Recently, metal-catalysed reactions have gained an important role in the macrocyclizations. These reactions are important because of the efficient formation of medium- and large-size rings, derived from the ability of the metal to coordinate at both ends of the acyclic substrate to pre-organize the system and reduce entropic costs.  However,  limited results are available for macrocyclization in synthesis of small cyclic peptides.  This poster describes our recent work on the synthesis of a series of conformationally constrained small cyclic peptides (di-, tri-, and tetra-) using Palladium catalyzed cyclizations, like Sonogashira coupling reaction, Heck reaction and Enyne Cycloisomerization.