Rh-catalyzed asymmetric hydrogenation of enamides

ORGN 665

Qin Yang, quy1@psu.edu, Wenzhong Gao, wug1@psu.edu, Jian Liao, jul10@psu.edu, and Xumu Zhang, xumu@chem.psu.edu. Department of Chemistry, 104 Chemistry Building, the Pennsylvania State University, University Park, PA 16802, State College, PA 16802
Chiral amines are often critical components of pharmaceutical agents. Recently, most attention of synthesis of enantiomerically pure amine has been devoted to asymmetric hydrogenation of enamide. We have developed a highly enantioselective Rh-Bis-phosphine catalyst for asymmetric hydrogenation of a series of substituted 2-(1-phenyl-vinyl)-isoindole-1,3-dione in good conversion (>98%) with high enantioselection (up to 99%).
 

Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005