AEI: Synthesis of derivatives of orotic acid

ORGN 416

Juliet M. Hahn1, Rachael Butcher2, Heather McPherson2, Valerie Campbell2, and Donna Fires2. (1) Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, OK 73019, (2) Department of Chemistry and Physics, Arkansas State University, P.O. Box 419, State University, AR 72467
Various derivatives of orotic acid were synthesized. Orotic acid, a derivative of uracil / thymine, is a degradation product of RNA / DNA and is a suspected carcinogen. The orotic acid derivatives are being synthesized to simulate the photodimerization of thymine, believed to be the primary mode of photochemical damage implicated in sunlight induced cancer. The synthesis of the derivatives and the photodimerization of some of the derivatives will be discussed
 

Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005