Fluorometric sensing of alkali metal and alkaline earth metal cations by novel photosensitive monoazacryptand derivatives in aqueous micellar solutions

ORGN 24

Yoshio Nakahara, nakahara@chem.eng.osaka-u.ac.jp, Departement of Tissue Engineering and Cell Therapy, Institute of Biomedical Research and Innovation, 2-2 Minatojima, Minamimachi, Chuo-ku, Kobe, 650-0047, Japan, Toshiyuki Kida, kida@chem.eng.osaka-u.ac.jp, Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan, Yohji Nakatsuji, nakatsuji@chem.oit.ac.jp, Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of Technology, 5-16-1 Omiya, Asahi-ku, Osaka, 535-8585, Japan, and Mitsuru Akashi, akashi@chem.eng.osaka-u.ac.jp, Center of Excellence (COE) Program for 21st Century, and Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.
The fluorescent detection of metal ions using fluorophores is one of the best methods to discriminate between metal cations including alkali metal and alkaline earth metal cations. Therefore, much effort has been devoted to the design and development of new types of fluorophores exhibiting high selectivity in addition to high sensitivity. However, most of them lose their specificity in aqueous media because their complexation abilities are drastically decreased by strong hydration. Recently, we reported a novel monoazacryptand type of fluorophore with a pyrene moiety, which detected Ba2+ in aqueous micellar solutions of Triton X-100 with high selectivity and sensitivity using fluorescence spectroscopy. In this study, we describe the design and synthesis of monoazacryptand types of fluorophores and their fluorescent characteristics in the presence of metal cations (Na+, K+, Mg2+, Ca2+) relevant to living organisms, in aqueous micellar solutions of nonionic surfactants and ionic surfactants.
 

Molecular Recognition and Self-Assembly
8:00 AM-12:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 201, Oral

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005