ORGN 401 |
| As part of our interest in transition metal-mediated cycloisomerization reactions we wish to further develop the rhodium catalyzed allenic Alder-ene reaction. We have recently expanded the scope of this reaction to include electron-deficient alkynes. Allenic ynones react under rhodium(I) conditions to afford cross-conjugated trienones in high yield and the reaction is generally tolerant of many types of substitution. Results of these studies will be presented and application of this methodology to the total synthesis of cassiol will also be discussed.
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |
