Enhancing the screening collection with drug-like developable molecules is a key goal for high throughput chemistry groups.  Toward this end, an efficient methodology for the solid-phase parallel synthesis of aminocarbonylbenzenesulfonamides has been developed.  Using high-loading 2,6-dimethoxy-4-polystyrenebenzyloxy-benzaldehyde (DMHB) resin, a 5,184-member array was prepared in high purity and yield via a six-step sequence.  The solid-phase reaction conditions were fully optimized and a variety of amines and aldehydes were scanned and used during array production.  A large percentage of the compounds prepared could directly be registered and submitted for biological screens without purification.  The reaction details, chemistry platform and analytical results will be described.