A solid-phase synthesis of N-[(1,4-cyclicdiaminocarbonyl)phenyl] arylsulfonamides using high-loading 2,6-dimethoxy-4-polystyrenebenzyloxy-benzaldehyde (DMHB) resin was developed and successfully applied to the preparation of a 5K-member array with four-points of diversity.  The key step, the monoacylation of unprotected symmetrical cyclic diamines with DMHB-resin bound benzoic acids, was selectively achieved without cross-linking side-reactions.  The synthetic methodology, coupled with using IRORI directed-sorting technology, made the array preparation quite successful.  The design, solid phase chemistry, monomer validation, and results will be described in the poster.