FLUO 2 |
| Artemisinin 1 is the antimalarial principle isolated from a plant used in traditional Chinese medicine. Artemisinin and artemisinin derivatives are very efficient against chloroquine-resistant strains of Plasmodium falciparum. However, they undergo in vivo a rapid biotransformation limiting the duration of the protection and recrudescence of parasitemia is often observed. Fluorine substitution is a new approach to design more metabolically stable artemisinin antimalarials. Some challenges regarding the synthesis of fluoroartemisinins as well the beneficial effects of fluorine substitution on the pharmacological behaviour of artemisinin derivatives will be presented.
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Current Frontiers of Fluoroorganic Chemistry
12:00 PM-4:35 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 146C, Oral
Division of Fluorine Chemistry |
