ORGN 16 |
| Polar biomolecules such as peptides, nucleic acids and proteins are potential drug candidates. Their bioavailability depends on their size, polarity and charge, which combine to limit their ability to efficiently cross the non-polar interior of biomembranes and reach intracellular targets. Consequently, most biomolecules are ruled out of many drug applications. A promising new method for drug delivery is the use of cell penetrating peptides (CPPs). Our group has developed a new class of oligocationic CPPs. Here, we report the synthesis of oligomers of mono/di-(2,2'-dipicolylamino) tyrosine, and partitioning behaviors of their zinc coordination complexes, as well as their cellular uptake.
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Molecular Recognition and Self-Assembly
8:00 AM-12:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 201, Oral
Division of Organic Chemistry |
