FLUO 3 |
| The incorporation of fluorine into organic molecules can be an effective strategy for improving and modifying the biological activity. Actually, the introduction of fluorine into key-positions of drug like molecules can be an effective way for optimizing and tuning their biological and/or pharmacological properties. Particular emphasis will be given to the effects of the introduction of a trifluoromethyl group that is recognized in medicinal chemistry as a substituent of distinctive qualities. In particular, its incorporation into some families of pharmacologically active agents, such as proteinase inhibitors having or not peptidomimetic structures and displaying anti-cancer, anti-HIV and anti-malaric activity could be a strategy for modifying the binding properties and the selectivity towards the targeted enzymes. Biological results and crystal structure analyses will help to verify the hypothesis. |
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Current Frontiers of Fluoroorganic Chemistry
12:00 PM-4:35 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 146C, Oral
Division of Fluorine Chemistry |