ORGN 214 |
| A new fluorous tag-assisted solution phase strategy allows not only the rapid, and potentially automated, modular synthesis of compounds, but also their direct use in forming microarrays on fluorous-derivatized surfaces. Application of this new concept to the synthesis of a variety of oligosaccharides and the formation of carbohydrate microarrays will be presented. Crucial to the success of this idea was the design of a potentially-removable but robust fluorous tag as well as the synthesis of an appropriately derivatized surface. Additionally, conditions for glycosylation reactions, deprotection steps, and purification using fluorous solid-phase extraction (SPE) have been developed that are amenable to future automation. Examples of tests for protein/carbohydrate interactions using the new microarrays and the advantages of this noncovalent fluorous microarray strategy for biological screening also will be presented. |
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Recent Advances in Fluorous Chemistry
8:00 AM-12:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Ballroom C, Oral
Division of Organic Chemistry |