ORGN 66 |
| Spirastrellolide A was isolated from marine sponge Spirastrellolide coccinea by Roberge et. al. in 2003. Spirastrellolide A was found not only to cause premature entry into mitosis and mitotic arrest in cells, but also to exhibit inhibitory activity of protein phosphatase PP2A (IC50 = 1 nM) along with a good selectivity for PP2A over PP1 (IC50 = 50 nM). Our synthesis of the C11-C23 fragment of Spirastrellolide A will be described in the presentation, which features a ketal – tethered RCM as an alternative approach to the construction of spiroketals.
|
|
Total Synthesis of Complex Molecules
1:00 PM-5:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 202B, Oral
Division of Organic Chemistry |
