Mixture of palladium catalysts for Suzuki cross-coupling reactions of aryl halides and pyridyl-2-boronic esters

ORGN 408

George Y. Li, george.y.li@combiphos.com1, Hua Cheng1, Haiqin Qi2, and Li Lu3. (1) CombiPhos Catalysts, Inc, P. O. Box 220, Princeton, NJ 08542-0220, (2) Vacational Technology College, Shenyang Normal University, 8 Songhua River Street, Huang-Gu District, Shenyang, China, (3) Department of Chemical Engineering, Dalian Institute of Light Industry, Dalian, China
Palladium catalysts are widely used for a variety of cross-coupling reactions in the formation of carbon-carbon, carbon-boron, carbon-nitrogen, carbon-sulfur bonds. However, in many cases, reaction requires different phosphorous ligands or different ratio of Pd/ligand to "fit" with each catalytic cycles, therefore no single catalyst can be applied for all cross-coupling reactions. We successfully found a mixture of air-stable metal-phosphinous acid compounds to be remarkably active and efficient catalysts for almost all Suzuki cross-coupling reactions of aryl halides with pyridine-2-boronic esters. Herein, we report a "combinatorial" mixture of air-stable palladium complexes served as efficient catalyst precursors for many C-C bond-forming reactions of aryl halides.
 

Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005