Short synthesis of lysergic acid via directed ortho metalation strategy

ORGN 29

Yigang Zhao, yzhao@chem.queensu.ca1, Victor Snieckus1, and Andrew L. Larkin2. (1) Department of Chemistry, Queen's University, 90 Bader Lane, Chernoff Hall, Kingston, ON K7L 3N6, Canada, (2) MV CEDD Medicinal Chemistry, GlaxoSmithKline, PO Box 13398, Five Moore Drive, Research Triangle Park, NC 27709
We report our efforts towards the synthesis of the ergot alkaloid, Lysergic Acid, using a Directed ortho Metalation (DoM)-Cross coupling strategy which intercepts the Hendrickson cyclization-intermediate in a potentially more concise and efficient manner.

 

Total Synthesis of Complex Molecules
8:00 AM-12:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 202B, Oral

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005