Biophysical characterization of c-di-GMP and its analogues in solution

ORGN 419

Zhaoying Zhang, zyzhang@rutchem.rutgers.edu1, Barbara L. Gaffney1, and Roger A. Jones2. (1) Department of Chemistry and Chemical Biology, State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, (2) Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08901
c-di-GMP was synthesized by a new method as well as the analogs c-IMP-GMP and several tethered c-di-GMP. Characterization of these molecules in the presence of different cations using UV and CD showed that c-di-GMP forms a higher order structure in K+ that is not present with the tethered dimers. Instead they may form a self intercalated structure.

 

Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005