ORGN 631 |
| Bis-indole molecules from natural sources have emerged for some years as promising research topics owing to their broad range of biological properties. Within this structural class, Caulersin and Caulerpin, isolated from the algae Caulerpa Serrulata can be distinguished by a seven- or eight- membered central ring respectively and an antiparallel arrangement of the two indole moieties. These structural singularities are a major synthetic challenge that we are taking up as part of our program dedicated to the search for new anticancer agents.
Three new access to Caulersin will be presented, based on the final generation of the seven- central ring by an intramolecular palladium Heck coupling or a Friedel-Craft type cyclization.
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Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Organic Chemistry |
