(-)-Agelastatin A is an architecturally unique antineoplastic tetracyclic metabolite isolated from marine sponge Agelas dedromorpha by Pietra and co-workers.  At low concentrations this alkaloid displays significant cytotoxicity against both L1210 and KB tumor cell lines as well as notable activity against a doxorubicin-resistant L1210 leukemia strain.  A concise total asymmetric synthesis of (-)-Agelastatin A has been achieved in 11 steps under eight operations (14% overall yield) using sulfinimine-based methodologies in which a syn-a,b-diamino ester was prepared stereoselectively via the addition of an N,N-dibenzyl protected glycine enolate to an enantiopure α,β-unsaturated (R)-sulfinimine.  Our procedure builds on earlier synthesis of this alkaloid by the groups of Weinreb, Feldman, and Hale, respectively.