ORGN 389 |
| Metal-catalyzed cycloaddition reactions represent a highly efficient and atom economical method to access heterocycles. For example, we discovered the combination of Ni and an appropriate ligand catalyzes the cycloaddition of alkynes and isocyanates to give pyridones. Employing bulky, N-heterocyclic carbene (NHC) ligands (such as 1,3-bis-(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene, SIPr) rather than phosphine ligands provided marked disparities in reactivity. Specifically, reaction conditions, product distribution, and pyridone regioselectivity differed between reactions. Mechanistic details of these processes will be discussed. |
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Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster
Sci-Mix
Division of Organic Chemistry |