ORGN 274 |
| Propargylic alcohols have been utilized in various ruthenium-catalyzed reactions including dimerization, cyclopropanation and Alder-ene reactions. Recently, our group reported a diastereoselective version of the ruthenium-catalyzed [2+2] cycloaddition between chiral propargylic alcohol and bicyclic alkenes. During the course of studying the scope of this reaction, unprecedented reactivity pathways were discovered. It was found that the size of the ring formed could be selected by altering the reaction components (alkene, alkynol) and conditions (solvent, ruthenium catalyst). Our preliminary mechanistic studies will also be discussed. |
|
Metal-Mediated Reactions and Syntheses
1:00 PM-5:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- 202B, Oral
Division of Organic Chemistry |