ORGN 23 |
| Asymmetric catalysis is very useful in the synthesis of optically active organic compounds. However an efficient asymmetric reaction relies on the successful selection of chiral catalysts and reaction conditions, most of which cannot usually be predicted and require time and labor consuming screening. In our lab, enantioselective fluorescent sensors were designed and synthesized in order to develop a rapid analytic tool for the high through-put chiral catalyst screening. Unlike the widely used HPLC and GC technique, fluorescence recognition could potentially greatly accelerate the analysis of chiral organic compounds. For example, we have synthesized the optically active macrocycle (S)- and (R)-1 recently. This compound shows a highly enantioselective fluorescent recognition of mandelic acid. A preliminary application of this sensor in chiral catalyst screening was also carried out and the results indicate that the enantioselective fluorescent sensors are very promising in the rapid assay of chiral molecules.
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Molecular Recognition and Self-Assembly
8:00 AM-12:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- 201, Oral
Division of Organic Chemistry |
