Fluorous enhanced combinatorial synthesis

ORGN 212

Wei Zhang, w.zhang@fluorous.com, University of Pittsburgh Applied Research Center, Fluorous Technologies, Inc, 970 William Pitt Way, UPARC, Pittsburgh, PA 15238
Fluorous synthesis is a new solution-phase synthetic technology which combines advantages of conventional solution-phase reactions with solid-phase type separations. This presentation describes the recent development at Fluorous Technologies, Inc. (FTI) in the synthesis of fluorous compounds (reagents, scavengers, protecting groups, and tags) and their applications in medicinal and library synthesis programs. Combinatorial technologies such as fluorous-enhanced microwave syntheses, multi-component reactions, diversity-oriented syntheses, plate-to-plate solid-phase extractions (SPE), and parallel HPLC purifications are also described.

 

Recent Advances in Fluorous Chemistry
8:00 AM-12:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Ballroom C, Oral

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005