MEDI 575 |
| Biocatalysis has become increasingly important for the preparation of chiral fine chemical and pharmaceutical intermediates. However, to fully exploit the potential of biocatalysis, access to novel enzymes with high activity, enhanced thermal and pH stability, and high chemo- regio- and enantioselectivity is necessary. Using high-throughput screening of genomic DNA libraries prepared from samples from diverse environments, we have assembled a collection of enzymes that catalyze a range of useful transformations. The challenges involved in progressing these enzymes from the initial discovery phase to the final process conditions will be discussed using aldolases, amidases, esterases and nitrilases as examples. |
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From Bench to Pilot Plant: Sponsored by Teledyne Isco, Inc
9:00 AM-12:00 PM, Thursday, 17 March 2005 Convention Center -- Room 6C, Oral
Division of Medicinal Chemistry |