Award Address (Ronald Breslow Award for Achievement in Biomimetic Chemistry, sponsored by The Ronald Breslow Endowment). Toward transcriptional therapy with programmable DNA binding oligomers

ORGN 400

Peter B. Dervan, dervan@caltech.edu, Department of Chemistry, California Institute of Technology, Mail Code 164-30, Pasadena, CA 91125
Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Synthetic molecules, programmed to read the DNA double helix by a set of simple chemical principles, achieve affinities and specificities comparable to DNA-binding proteins. Current research efforts are focused on the regulation of endogenous genes in cell culture, and the design of artificial transcription factors.
 

Ronald Breslow Award for Achievement in Biomimetic Chemistry
1:40 PM-5:05 PM, Tuesday, 15 March 2005 Convention Center -- Ballroom 20 C-D, Oral

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005