CARB 5 |
| It is well established that cell surface carbohydrates play unique roles in a host of biologically relevant events such as cell differentiation, adhesion and motility. In addition, the altered expression of surface glycans on various tumor cells creates “non-self” structures that can be recognized by the immune system and also contribute to tumor aggressiveness and metastasis. In this presentation, we describe two separate nanometer-sized particles that can display multiple copies of carbohydrates on their surface and be used for the study of carbohydrate-mediated cellular events. Three-dimensional self-assembled monolayers of gold bearing various carbohydrates have been prepared and assessed for their antitumor properties. In addition, we have developed a new synthesis of carbohydrate-bearing quantum dots that possess size-tunable luminescent features that make them attractive reagents for biological imaging. The talk will outline the preparation and properties of these nanoparticles and highlight their therapeutic and diagnostic potential. |
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Frontiers in Modern Carbohydrate Chemistry
8:30 AM-12:00 PM, Sunday, 13 March 2005 San Diego Marriott -- San Diego A, Oral
Division of Carbohydrate Chemistry |