CHED 447 |
| Synthesis of a histidine analog to probe the structure-activity relationship of the interaction of the short peptide glucagon-like peptide-1 (GLP-1) with its receptor GLP-1R, has been pursued. Through biochemical studies, the N-terminal histidine of GLP-1 has been shown to be necessary for activation of GLP-1R, but less important for binding. Synthesis of the histidine analog 3-triazolylalanine (1) has been attempted from triazole through reaction with the appropriate protected amino acrylate. Enantiomeric resolution can be achieved enzymatically. Synthetic challenges and results will be discussed.
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Undergraduate Research Poster Session: Organic Chemistry
11:15 AM-1:15 PM, Monday, 14 March 2005 Convention Center -- Hall D, Poster
Division of Chemical Education |
