Photoinduced DNA cleavage by aryl sulfoxides

CHED 463

David P. Turner, ahpred@wharf.ship.edu and Allison H. Predecki, ahpred@ship.edu. Department of Chemistry, Shippensburg University, 1871 Old Main Drive, Shippensburg, PA 17257
The capability of phenyl sulfoxide (1) and methyl phenyl sulfoxide (2) to photoinduce strand cleavage in plasmid DNA has been investigated. The results of plasmid relaxations assays will be discussed. Mechanistic experiments to determine the species responsible for DNA cleavage will also be presented.

 

Undergraduate Research Poster Session: Organic Chemistry
11:15 AM-1:15 PM, Monday, 14 March 2005 Convention Center -- Hall D, Poster

Division of Chemical Education

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005