ORGN 658 |
| Discovery of new small molecules requires novel synthetic strategies. Diversity oriented synthesis (DOS) constitutes a powerful concept for synthesizing collections of small molecules that will have an impact on biology, either as tools or pharmacological agents. The DOS approach used most frequently involves sequential reactions whereby substructures are incorporated into scaffolds of growing complexity, thereby creating diversity. An alternative and less common approach involves the construction of a pivotal compound that, when subjected to the appropriate reagents or catalyst, can give new, structurally distinct products. Transition metal-catalyzed processes are ideal for these reagent controlled diversification strategies since seemingly small changes in the reaction conditions or catalyst can lead to remarkable changes in the bonds formed and broken during the synthetic transformation. A diverging strategy for the synthesis of a collection of heterocyclic compounds via new allenic carbocyclization reactions will be presented along with details of the issues contributing to the stereo- and regioselectivity and reaction pathway. |
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Nakanishi Prize
1:00 PM-5:00 PM, Wednesday, 16 March 2005 Convention Center -- Ballroom 20A-B, Oral
Division of Organic Chemistry |