The syntheses of rigidified glutamate with piperidine skeleton: Homokainic acids

ORGN 126

Wen Hua Chiou, wchiou@ic.sunysb.edu1, Angele Schoenfelder2, Andre Mann2, and Iwao Ojima, iojima@notes.cc.sunysb.edu3. (1) Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400, (2) Faculte de Pharmacie, Laboratoire de Pharmacochimie de la Communication Cellulaire, Illkirch, 67401, France, (3) Department of Chemistry and ICB&DD, State University of New York at Stony Brook, The Chemistry Bldg, Stony Brook, NY 11794-3400
The chimera between glutamic and pipecolic acids produces constrained glutamate analogues, interesting for the exploration of the glutamate receptor which is involved in the mamalian brain for many functions such as memory or dysfunction such as neuronal degradation. Cyclohydrocarbonylation provides a powerful and divergent tool to reach the targets. This paper will present our progress in the syntheses of these rigidified glutamic acids - homokainic acids .

 

Heterocycles, Aromatics, Materials, Devices, Switches, Combinatorial Chemistry, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, 13 March 2005 Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005