ORGN 256 |
| Thiamin pyrophosphate is an essential cofactor in all-living systems and consists of a pyrimidine covalently linked to a thiazole. The biosynthesis of thiamin is complex and different from any of the characterized chemical or biochemical routes to these heterocycles. The thiazole is formed from deoxy-D-xylulose-5-phosphate, glycine and a protein thiocarboxylate in a reaction catalyzed by four enzymes, while the pyrimidine is formed by a remarkable rearrangement of aminoimidazole ribotide. This lecture will describe the current status of our mechanistic and structural studies on the thiamin biosynthetic enzymes in bacteria. |
|
Frontiers in Bio-organic Chemistry and Chemical Biology
8:00 AM-11:55 AM, Monday, 14 March 2005 Convention Center -- Ballroom 20 C-D, Oral
Division of Organic Chemistry |