ORGN 510 |
| Enyne metathesis efficiently produces 1, 3-dienes which are synthetically useful building blocks. Linking the alkyne and alkene functionalities through a silyloxy tether renders the process intramolecular, allowing for better regio- and stereochemical control in the resulting conjugated vinylsilane. Recent work has lead to two consecutive reactions catalyzed by two different ruthenium catalysts to form siloxacycles from alkenyl carbenols and alkynylsilanes. The current study reports the use of a single catalyst to achieve two different catalytic reactions, dehydrogenative condensation between alcohols and silanes and ring closing metathesis of the silyoxy enynes, simply by modulating the reactivity of the metal with different ligands. |
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New Reactions, Methodology, Total Synthesis, Physical Organic Chemistry
8:00 PM-10:00 PM, Tuesday, 15 March 2005 Convention Center -- Sails Pavilion, Poster
Division of Organic Chemistry |