Studies on the self-assembly of guanosine analogues in aqueous media

ORGN 726

Marilyn García-Arriaga, mgayjnr@yahoo.com1, Sandra Méndez, mgayjnr@yahoo.com1, and José M. Rivera, jrivera@cnnet.upr.edu2. (1) Department of Chemistry, University of Puerto Rico, Río Piedras Campus, San Juan, PR 00931-3346, (2) Department of Chemistry, University of Puerto Rico at Rio Piedras, Río Piedras, PR 00931
Guanosine forms supramolecular structures known as G-quadruplexes in which four gua-nine bases form a tetrad and two or more of such tetrads can stack using a metal cation like potassium as a template. Recently, we showed that lipophilic 8-arylguanosine ana-logues can also form quadruplexes in organic media and that the 8-aryl group influences the properties of the resulting assembly. We will present our initial studies on the self-assembling behavior of related water-soluble analogues in aqueous media. In particular, we will discuss our synthetic efforts to increase the solubility in water of such analogues and the characterization of their self-assembling by means of NMR, UV and CD spectro-scopic methods.

 

Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster

Division of Organic Chemistry

The 229th ACS National Meeting, in San Diego, CA, March 13-17, 2005