ORGN 732 |
| This paper introduces the unnatural amino acid, 4'-amino-[1,1'-biphenyl]-4-carboxylic acid, termed Abc, which is designed as a nanometer-length building block for the creation of molecular rods. Water-soluble oligomers of AbcK, a variant of Abc named for its resemblance to the side chain of lysine, can be synthesized from Fmoc-AbcK(Boc)-OH using standard solid-phase peptide synthesis technology to create rodlike molecules of any desired length. Herein, we report the synthesis of Fmoc-AbcK(Boc)-OH and its efficient coupling to generate water-soluble oligomers of defined length.
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Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster
Division of Organic Chemistry |
