ORGN 730 |
| This paper presents a new class of bivalent macrocyclic β-sheets that consist of two linked cyclic modular β-sheets and are designed to inhibit the aggregation of β-amyloid. The cyclic modular β-sheets, which are composed of two δ-ornithine turn units [JACS 2003, 125, 876] and the unnatural amino acid β-strand template Hao [JACS 2000, 122, 7654], robustly fold in aqueous solvents. Synthetic and structural studies will be described and the application of molecular modeling to the design of β-amyloid aggregation blockers will be discussed. Ongoing efforts to inhibit β-amyloid aggregation will also be presented.
|
|
Asymmetric Reactions, Molecular Recognition, Self Assembly, Bioorganic Chemistry, Process R&D
8:00 PM-10:00 PM, Wednesday, 16 March 2005 Convention Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
